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Encequidar mesylate (HM30181A mesylate) 是竞争性有效的 P-糖蛋白抑制剂。
Encequidar mesylate (HM30181A mesylate) 是竞争性有效的 P-糖蛋白抑制剂。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 228 | 现货 | |
5 mg | ¥ 546 | 现货 | |
10 mg | ¥ 753 | 现货 | |
25 mg | ¥ 1,450 | 现货 | |
50 mg | ¥ 2,380 | 现货 | |
100 mg | ¥ 3,650 | 现货 | |
500 mg | ¥ 7,860 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 648 | 现货 |
产品描述 | Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor. |
体外活性 | Treatment of 0.1 or 1 nM Encequidar lead to 20 and 42% inhibition of survival at the 100 nM and 1000 nM NSC 125973 treatment, respectively [2]. |
体内活性 | The plasma concentrations of Encequidar are higher for the simultaneous administration with the microcapsule than with the powder; providing significant differences from 1 to 2 h. The microcapsule has about a 1.7-fold faster Tmax and a 1.6-fold higher AUC value compared with the powder (2.5±0.6 vs. 4.3±0.9 h; 107.7±20.1 vs. 64.3±18.0 h ng/mL). The faster and overall improved absorption of Encequidar in microcapsule form might be due to the remarkable enhancement of the aqueous solubility and dissolution resulting from its crystalline conversion to the amorphous form and particle size reduction [1]. |
别名 | HM30181 mesylate, HM30181A mesylate |
分子量 | 784.83 |
分子式 | C39H40N6O10S |
CAS No. | 849675-87-2 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 55 mg/mL (70.08 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
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DMSO
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